NAD⁺ (nicotinamide adenine dinucleotide) is the spark plug of your cells. Without it, your mitochondria — the energy factories of your body — can't function. DNA repair slows. Inflammation rises. And aging accelerates.
By the time you're 50, your NAD⁺ levels may have dropped by more than 50%. If you’re feeling chronically tired, foggy, or aging faster than you’d like, your NAD⁺ status might be the missing piece.
⚡ What Is NAD⁺?
NAD⁺ is a coenzyme found in every cell. It’s essential for:
- Cellular energy (ATP) production
- DNA repair and cellular maintenance
- Immune system regulation
- Sirtuin activation – longevity-linked genes that protect against aging
📉 Why NAD⁺ Declines With Age
Your body naturally produces less NAD⁺ as you age. But modern lifestyles accelerate this decline:
- Chronic stress
- Alcohol and tobacco use
- Poor sleep or circadian disruption
- Inflammation and metabolic dysfunction
⚠️ Symptoms of Low NAD⁺
- Fatigue and low stamina
- Brain fog or slower thinking
- Delayed recovery after stress or exercise
- Signs of premature aging
Because NAD⁺ supports over 500 enzymatic reactions, its decline affects everything from metabolism to cognition.
🧪 How to Measure Your NAD⁺ Status
The NAD⁺ Index Test provides a complete picture of your cellular energy and niacin (vitamin B3) metabolism. It measures:
- NAD⁺ and NADH – the oxidized and reduced forms of the core coenzyme
- NADP⁺ and NADPH – involved in antioxidant defense and biosynthesis
- NAD/NADH and NADP/NADPH ratios
- Nicotinamide (NAM) and Nicotinic Acid (NA) – vitamin B3 metabolites
This comprehensive test helps identify whether you're depleted, balanced, or at risk of dysfunction — all from a dried blood spot sample at home.
💊 How to Boost NAD⁺ Naturally
- NMN or NR supplements – direct NAD⁺ precursors
- Exercise – boosts NAD⁺ biosynthesis pathways
- Intermittent fasting – activates sirtuins and NAD⁺ production
- Good sleep – restores mitochondrial efficiency
- Minimising alcohol and processed sugar
However, response to supplementation varies — that’s why testing first is key.
🎯 Why Test NAD⁺ Levels?
NAD⁺ supplements are expensive. Testing gives you data to:
- See if you actually need supplementation
- Tailor your dose for efficiency and safety
- Track how your levels change with supplements, fasting, or training
Don’t guess. Test. Rebuild your cellular engine from the inside out with our NAD⁺ Index Test.
🔎 FAQs About NAD⁺ and the NAD⁺ Index Test
What’s the difference between NAD⁺ and NADH?
NAD⁺ is the oxidized form, while NADH is the reduced form. They work as a pair, enabling energy transfer in your cells. Balanced ratios are key for mitochondrial health.
Can I test NAD⁺ at home?
Yes. The NAD⁺ Index Test is a dried blood spot test you complete at home and return by post. It’s analysed using LC-MS/MS for high accuracy.
What does the NAD/NADH ratio tell me?
This ratio is a key marker of cellular redox status and mitochondrial health. A low ratio can signal energy dysfunction or oxidative stress.
Do I need to stop supplements before testing?
If you're already taking NMN or NR, continue if you want to see your current levels. If you're establishing a baseline, pause for 5–7 days unless advised otherwise by a practitioner.
